It was a foregone conclusion as England's serene progress through the preliminary stage resulted in an confirmed slot at the 2026 World Cup.
Anthony Gordon netted the first goal in the first half, curling a exquisite strike into the opposite side of the net.
Harry Kane followed up with a quickfire two goals before the interval—initially with a low drive from the penalty arc, and later from the 12-yard mark after a confirmed infraction.
The visitors notched two further strikes in the second period—one an own goal by a Latvian replacement, and another a clinical finish from the substitute.
Throughout the match, the visiting supporters voiced good-natured taunts at manager Thomas Tuchel, responding to his criticism about the Wembley crowd.
Messages such as "We'll sing when we want" and "How's the volume?" rang out around the small ground.
England kept their flawless clean sheet run in qualifying, securing their latest clean sheet.
Goalkeeper Jordan Pickford extended his individual streak of shutouts for the national side to nine games.
Now guaranteed a spot, England can turn their attention to training for the finals tournament.
Final games still remain in the qualifying group, but England has effectively topped the group with a 100% record.
"It was a professional display from the squad, and they did what was needed against determined rivals."